February 11, 2021

Lasting Antibody and T Cell Responses to SARS-CoV-2 in COVID-19 Patients Three Months after Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

In a longitudinal study of 25 convalescent SARS-CoV-2 positive patients, approximately 65% of patients had detectable T cell responses 3-4 months post-symptom onset (PSO) despite all patients seroconverting. All patients had detectable IgG against the nucleocapsid (N) and spike (S) protein as well as detectable IgG and IgM responses against the receptor-binding domain (RBD); all patients also produced neutralizing antibodies (nAbs) by 14 days PSO. Peak antibody levels were observed 15-30 days PSO, with IgG and nAb levels detected up to 3-4 months PSO and IgM levels declining much more rapidly.

Jiang et al. (Feb 9, 2021). Lasting Antibody and T Cell Responses to SARS-CoV-2 in COVID-19 Patients Three Months after Infection. Nature Communications. https://doi.org/10.1038/s41467-021-21155-x