Alliance for Pandemic Preparedness

February 13, 2021

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial

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Results of a randomized trial among 214 patients with lab-confirmed COVID-19 suggest that high-dose zinc, high-dose ascorbic acid (vitamin C), and a combination of the two do not significantly change the duration of symptoms. Patients who received usual care without supplementation achieved a 50% reduction in symptoms at a mean of 6.7 days compared with 5.5 days for the ascorbic acid group, 5.9 days for the zinc gluconate group, and 5.5 days for the group receiving both. There was no significant difference in secondary outcomes among the treatment groups.

Thomas et al. (Feb 12, 2021). Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Network Open. https://pubmed.ncbi.nlm.nih.gov/33576820/