Alliance for Pandemic Preparedness

February 13, 2021

Impact of Age, Ethnicity, Sex and Prior Infection Status on Immunogenicity Following a Single Dose of the BNT162b2 MRNA COVID-19 Vaccine: Real-World Evidence from Healthcare Workers, Israel, December 2020 to January 2021

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A single dose of the Pfizer SARS-CoV-2 vaccine produced detectable anti-SARS-CoV-2 spike IgG antibodies 21 days after vaccination in 92% (n=475) of a cohort of healthcare workers in Israel, including in 92% (n=458) of people who had no history of COVID-19 infection. The 39 healthcare workers who did not respond to the first dose were older (mean age 57) than those who did (mean age 45). Among those with antibodies after vaccination, IgG titers decreased with increasing age, although the authors note that the decrease was small and of unclear clinical significance. In people with a history of COVID-19, the single vaccine dose was associated with IgG titres approximately one order of magnitude higher compared with vaccinated individuals with no prior history of COVID-19.

Abu Jabal et al. (Feb 11, 2021). Impact of Age, Ethnicity, Sex and Prior Infection Status on Immunogenicity Following a Single Dose of the BNT162b2 MRNA COVID-19 Vaccine: Real-World Evidence from Healthcare Workers, Israel, December 2020 to January 2021. Eurosurveillance. https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096