February 16, 2021

Discrete SARS-CoV-2 Antibody Titers Track with Functional Humoral Stability

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

There may be a distinct threshold of immune activity, defined by the level of antibodies, in response to SARS-CoV-2 infection that is required to elicit a vigorous humoral and cellular response necessary to prevent subsequent re-infection. These conclusions were based on a community-based surveillance study of 120 SARS-CoV-2 convalescent patients, which found that sustained functional humoral responses were mostly observed in individuals who had antibody titers to the SARS-CoV-2 receptor binding domain (RBD) that were above a certain threshold. The authors note that unlike mild/asymptomatic natural infection, vaccine boosting is likely to result in the induction of broad robust protective immunity.

Bartsch et al. (Feb 2021). Discrete SARS-CoV-2 Antibody Titers Track with Functional Humoral Stability. Nature Communications. https://www.nature.com/articles/s41467-021-21336-8