February 17, 2021

CD8+ T Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, variants

[Pre-print, not peer-reviewed] A study assessing whether CD8+ T-cells from COVID-19 convalescent individuals (n=30) can recognize SARS-CoV-2 variant epitopes showed that only one of the three most prominent variants (the B.1.351 variant, first described in South Africa) had a mutation that overlapped with a low-prevalence CD8+ epitope. Out of 45 mutations assessed, this mutation was found on the third residue of the epitope. The authors argue that these findings suggest that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

Redd et al. (Feb 2021). CD8+ T Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants. Pre-print downloaded Feb 17 from https://doi.org/10.1101/2021.02.11.21251585