Alliance for Pandemic Preparedness

February 22, 2021

SARS-CoV-2 Shedding Dynamics Across the Respiratory Tract Sex and Disease Severity for Adult and Pediatric COVID-19

Category:

Topic:

Keywords (Tags):

[Pre-print, not peer-reviewed] A systematic review and pooled analysis of SARS-CoV-2 shedding dynamics in the upper (URT) and lower (LRT) respiratory tracts found that severe COVID-19 in adults was characterized by high, persistent shedding of SARS-CoV-2 virus in the LRT. In the URT, adults with severe COVID-19 had higher respiratory viral loads 1 day post-symptom onset than adults or children with non-severe illness. Between 1-10 days post-symptom onset, SARS-CoV-2 clearance from the URT was similar among adults with severe illness compared to adults and children with non-severe illnesses. In the LRT, adults with severe COVID-19 showed higher respiratory viral loads post-symptom onset than adults with non-severe COVID-19.

Chen et al. (Feb 19, 2021). SARS-CoV-2 Shedding Dynamics Across the Respiratory Tract Sex and Disease Severity for Adult and Pediatric COVID-19. Pre-print downloaded Feb 22 from https://doi.org/10.1101/2021.02.17.21251926