Alliance for Pandemic Preparedness

February 23, 2021

Longitudinal Analysis of SARS-CoV-2 Antibodies in 8000 U.S. First-time Convalescent Plasma Donations

Category:

Topic:

Keywords (Tags):

The average SARS-CoV-2 IgG levels among first-time US COVID-19 convalescent plasma donations have dropped significantly, according to a longitudinal analysis of 8,749 plasma units collected from April to September 2020. The decrease in mean IgG values were significantly correlated with decreases in mean plasma donor age and the percentage of units obtained from donors who had been hospitalized. The highest titer plasma units were obtained from acutely convalescent COVID-19 patients requiring hospitalization, and advanced age donors.

Karbiener et al. (Feb 22, 2021). Longitudinal Analysis of SARS-CoV-2 Antibodies in 8000 U.S. First-time Convalescent Plasma Donations. Transfusion. https://doi.org/10.1111/trf.16291