Alliance for Pandemic Preparedness

February 25, 2021

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

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In a nationwide case series of 1116 patients <21 years between March and October 2020, 539 were diagnosed with multisystem inflammatory syndrome in children (MIS-C) and 577 were diagnosed with COVID-19. Patients with MIS-C were more likely to be 6-12 years old (41% vs 19%), non-Hispanic Black (32% vs 22%), and have severe cardiovascular symptoms than respiratory symptoms (56% vs 9%) than COVID-19 patients. A higher proportion of MIS-C patients were admitted to the ICU (74% vs 44%), and a similar proportion died during hospitalization (1.9% vs 1.4%).

Feldstein et al. (Feb 24, 2021). Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. https://doi.org/10.1001/jama.2021.2091