Alliance for Pandemic Preparedness

February 26, 2021

Obesity May Hamper SARS-CoV-2 Vaccine Immunogenicity



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  • [pre-print; not peer-reviewed] Antibody titers two weeks after receiving a second dose of the Pfizer-BioNTech vaccine were lower in obese healthcare workers (BMI >30), after adjusting for age. 99.5% of the 248 participants developed a humoral immune response after vaccination, and antibody titers were higher in younger people and in women. The authors note that the importance of the magnitude of a humoral response is still under investigation. 

Pellini et al. (Feb 26, 2021). Obesity May Hamper SARS-CoV-2 Vaccine Immunogenicity. Pre-print downloaded Feb 26 from