March 1, 2021

Antibodies with Potent and Broad Neutralizing Activity against Antigenically Diverse and Highly Transmissible SARS-CoV-2 Variants

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): immunity, treatment, variants

• [Pre-print, not peer-reviewed] A study identifying the structural and functional determinants of serum with broad neutralization of SARS-CoV-2 determined that combinations of two antibodies with broadly neutralizing activity decrease the in vitro generation of escape mutants. The structural characteristics of four monoclonal receptor-binding domain-targeting antibodies isolated from three early-outbreak convalescent donors with broadly neutralizing polyclonal serum were described. Individual neutralizing activity of each monoclonal antibody against 12 variants (including B.1.1.7 and B.1.351) was characterized and two of the four antibodies studied (A23-58.1 and B1-182.1) were defined as ultrapotent. Serum was originally obtained from five convalescent donors infected by the original SARS-CoV-2 outbreak strain (WA-1, identified in Washington state).

Wang et al. (Feb 26, 2021). Antibodies with Potent and Broad Neutralizing Activity against Antigenically Diverse and Highly Transmissible SARS-CoV-2 Variants. Pre-print downloaded Mar 1 from https://doi.org/10.1101/2021.02.25.432969