March 1, 2021

Antibody Response to First BNT162b2 Dose in Previously SARS-CoV-2-Infected Individuals

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccines

• A nested case-control study of 51 health care workers found that anti-S titers 19-29 days after the first dose of the Pfizer/BioNTech vaccine were comparable to peak titers after natural infection. Among those with a previous SARS-CoV-2 infection, vaccination increased anti-S titers more than 140-fold from peak pre-vaccine levels. Prior infection was determined by positive detection of antibodies against the SARS-CoV-2 nucleocapsid or the receptor binding domain of the SARS-CoV-2 S1 subunit of the spike protein.

Manisty et al. (Feb 26, 2021). Antibody Response to First BNT162b2 Dose in Previously SARS-CoV-2-Infected Individuals. The Lancet. https://doi.org/10.1016/S0140-6736(21)00501-8