Alliance for Pandemic Preparedness

March 2, 2021

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

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  • A single dose of mRNA vaccine (Pfizer or Moderna vaccine) elicited higher antibody and neutralization titers in health care workers (n=59) with previous serology-confirmed SARS-CoV-2 infection compared to healthcare workers who were seronegative at baseline. At 14 days post-vaccination, antibody binding strength to SARS-CoV-2 antigens from participants with both asymptomatic and symptomatic prior infection were up to 38-fold higher compared to those seronegative at baseline. Similarly, neutralizing titers were several orders of magnitude higher among those with prior infection when compared to seronegative participants.

Saadat et al. (Mar 1, 2021). Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2. JAMA. https://doi.org/10.1001/jama.2021.3341