March 2, 2021

Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, sequelae

• [Pre-print, not peer-reviewed] A longitudinal study in California found that SARS-CoV-2-specific T cell responses remained largely stable up to 9 months following SARS-CoV-2 infection (n=70). Stronger CD4+ T cell responses were associated with initial disease severity as well as neutralizing antibody levels, whereas pre-existing lung disease predicted long-term CD8+ T cell responses. While 36% of participants had COVID-19-related symptoms persisting approximately 4 months after initial illness (median 125 days), no substantial differences in long-term T cell or antibody responses were identified between participants with or without persisting symptoms.

Peluso et al. (Mar 1, 2021). Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19. Pre-print downloaded Mar 2 from https://doi.org/10.1101/2021.02.26.21252308