Alliance for Pandemic Preparedness

March 2, 2021

Negligible Impact of SARS-CoV-2 Variants on CD4+ and CD8+ T Cell Reactivity in COVID-19 Exposed Donors and Vaccinees

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  • [Pre-print, not peer-reviewed] Bioinformatic analysis suggests that memory T cells generated either by mild SARS-CoV-2 infection (n=11) or mRNA vaccines will not be affected by currently circulating variants. No significant differences were found in the capacity of CD4+ or CD8+ T cells isolated either from convalescent patients following mild disease or vaccinated individuals to recognize a pool of S protein peptides in any lineage tested. These peptides corresponded either to the parental reference SARS-CoV-2 strain isolated from Wuhan or the different variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C.

Tarke et al. (Mar 1, 2021). Negligible Impact of SARS-CoV-2 Variants on CD4+ and CD8+ T Cell Reactivity in COVID-19 Exposed Donors and Vaccinees. Pre-print downloaded Mar 2 from https://doi.org/10.1101/2021.02.27.433180