Alliance for Pandemic Preparedness

March 2, 2021

Reduced Antibody Cross-Reactivity Following Infection with B.1.1.7 than with Parental SARS-CoV-2 Strains

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  • [Pre-print, not peer-reviewed] Convalescent sera from patients infected with the SARS-CoV-2 B.1.1.7 variant demonstrated reduced activity against reference strains from earlier in the pandemic. Neutralizing activity of sera isolated from patients that had confirmed infection by the SARS-CoV-2 B.1.1.7 variant (n=29) was reduced against a parental reference strain isolated from Wuhan by 3.4-fold. In contrast, sera isolated from patients infected with the D614G variant (n=37) had similar neutralizing titers against the both the B.1.1.7 variant and the parental reference strain. Meanwhile, both D614G and B.1.1.7 sera displayed significantly reduced neutralization of the B.1.351 variant by 8.2- and 7.7-fold, respectively. 

Faulkner et al. (Mar 1, 2021). Reduced Antibody Cross-Reactivity Following Infection with B.1.1.7 than with Parental SARS-CoV-2 Strains. Pre-print downloaded Mar 2 from https://doi.org/10.1101/2021.03.01.433314