Alliance for Pandemic Preparedness

March 3, 2021

Early Effectiveness of COVID-19 Vaccination with BNT162b2 MRNA Vaccine and ChAdOx1 Adenovirus Vector Vaccine on Symptomatic Disease Hospitalisations and Mortality in Older Adults in England

Category:

Topic:

Keywords (Tags):

  • [Pre-print, not peer-reviewed] A study of the real-world effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines in the UK indicated that vaccination with a single dose of either vaccine was associated with a significant reduction in symptomatic COVID-19 cases in older adults, with strong protection against severe disease. Effects of the Pfizer-BioNTech vaccine among adults 80 and older were observed 10-13 days after vaccination, reaching an effectiveness of 70% from 28-34 days. From 14 days after the second dose, vaccine efficacy was 89%. For those 70 and older, vaccine effectiveness reached 61% from 28-34 days after vaccination. With the Oxford-AstraZeneca vaccine, vaccine effects were seen from 14-20 days after vaccination, efficacy was 60% from 28-34 days, and increased to 73% from day 35 onwards.

Bernal et al. (Mar 2, 2021). Early Effectiveness of COVID-19 Vaccination with BNT162b2 MRNA Vaccine and ChAdOx1 Adenovirus Vector Vaccine on Symptomatic Disease Hospitalisations and Mortality in Older Adults in England. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2021.03.01.21252652