Alliance for Pandemic Preparedness

March 4, 2021

Delayed Large Local Reactions to MRNA-1273 Vaccine against SARS-CoV-2

Category:

Topic:

Keywords (Tags):

  • A case series of 12 patients reported delayed large local reactions (skin redness, tenderness and swelling) in response to the Moderna vaccine within 4 to 11 days (median 8 days) after the first dose. In all cases, the reactions appeared near the injection site after complete resolution of the initial local and systemic symptoms associated with vaccination. 5 of the 12 reactions were 10 cm or larger in diameter. Most patients received treatment, and symptoms resolved within 2 to 11 days of onset (median 6 days). After receiving the second vaccine dose, 3 patients had recurrent reactions similar to the reaction after the first dose and 3 patients had lower grade reactions. 

Blumenthal et al. (Mar 3, 2021). Delayed Large Local Reactions to MRNA-1273 Vaccine against SARS-CoV-2. New England Journal of Medicine. https://doi.org/10.1056/NEJMc2102131