March 5, 2021

Age-Dependent Immune Response to the BioNtech-Pfizer BNT162b2 COVID-19 Vaccination

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, vaccination

• [Pre-print, not peer-reviewed] Among 176 participants receiving two doses of the Pfizer-BioNTech vaccine in a cohort study in Germany, participants aged >80 years had lower SARS-CoV-2 specific IgG antibody titers and neutralizing titers compared to participants aged <60 years after each dose. While the IgG titer increase between the first and second dose was larger among older participants, mean IgG titers 17 days after the second dose were much lower compared to younger participants. The neutralizing antibody response was similarly lower in older recipients, with only 69% of older participants having detectable neutralizing antibody titers 17 days after the second dose, compared to 98% of younger participants.

Müller et al. (Mar 5, 2021). Age-Dependent Immune Response to the BioNtech-Pfizer BNT162b2 COVID-19 Vaccination. Pre-print downloaded Mar 5 from https://doi.org/10.1101/2021.03.03.21251066