Alliance for Pandemic Preparedness

March 5, 2021

Articles Risk of Adverse Outcomes in Patients with Underlying Respiratory Conditions Admitted to Hospital with COVID-19: A National, Multicentre Prospective Cohort Study Using the ISARIC WHO Clinical Characterisation Protocol UK

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  • Asthma was associated with a higher likelihood over developing more severe COVID-19. Among more than 75,000 patients hospitalized with COVID-19 in the UK from January to August 2020, patients with asthma were 1.2-times as likely to receive critical care compared to patients without underlying respiratory conditions, regardless of comorbidities and disease severity at admission. Patients aged 16 years and older with severe asthma had a significantly higher risk of mortality than those with no asthma (aOR=1.2). Patients aged 50 and older with chronic pulmonary disease were less likely than those without a respiratory condition to receive critical care regardless of asthma status, but had a 1.2-fold higher mortality risk regardless of inhaled corticosteroid use. However, use of inhaled corticosteroids within 2 weeks of admission was associated with a 14% reduction in mortality risk.

Bloom et al. (Mar 4, 2021). Articles Risk of Adverse Outcomes in Patients with Underlying Respiratory Conditions Admitted to Hospital with COVID-19: A National, Multicentre Prospective Cohort Study Using the ISARIC WHO Clinical Characterisation Protocol UK. The Lancet Respiratory Medicine. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00013-8/fulltext