Alliance for Pandemic Preparedness

March 8, 2021

Comparison of IgG and Neutralizing Antibody Responses after One or Two Doses of COVID-19 MRNA Vaccine in Previously Infected and Uninfected Persons

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  • [Pre-print, not peer-reviewed] A community-based, home-collected, longitudinal serosurvey of 290 participants before and after vaccination with either the Moderna or Pfizer/BioNTech vaccines found that a prior outpatient COVID-19 diagnosis was associated with strong anti-spike RBD IgG and in vitro neutralizing responses after one vaccine dose. Median IgG concentration and percent neutralization after one dose were each significantly higher among seropositive individuals who reported prior COVID-19 diagnosis (median 47.7 ug/ml, IgG; >99.9% neutralization) compared to those who were seropositive with no history of diagnostic testing (3.4 ug/ml IgG; 62.8% neutralization) and those who were seronegative (2.2 ug/ml IgG; 39.5% neutralization). The latter two groups reached >95% neutralization after the second dose.

Demonbreun et al. (Mar 8, 2021). Comparison of IgG and Neutralizing Antibody Responses after One or Two Doses of COVID-19 MRNA Vaccine in Previously Infected and Uninfected Persons. Pre-print downloaded Mar 8 from https://doi.org/10.1101/2021.03.04.21252913