Alliance for Pandemic Preparedness

March 9, 2021

Acute Allergic Reactions to MRNA COVID-19 Vaccines



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  • Among employees of Mass General Brigham (MGB), a Boston-based hospital and physicians network, who received their first dose of either the Pfizer-BioNTech or Moderna vaccine (n=64,900), acute allergic reactions of any type were reported by 1,365 employees overall (2.1%) and anaphylaxis was reported by 16 employees (2.5 cases per 10,000 vaccinations).. Among those reporting anaphylaxis, 63% had a prior allergy history and 31% had a history of anaphylaxis.

Blumenthal et al. (Mar 8, 2021). Acute Allergic Reactions to MRNA COVID-19 Vaccines. JAMA.