March 9, 2021

SARS-CoV-2-Specific T Cell Memory Is Sustained in COVID-19 Convalescents for 8 Months with Successful Development of Stem Cell-like Memory T Cells

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• [Pre-print, not peer-reviewed] Whole blood analysis from 94 individuals who had been infected with SARS-CoV-2 in South Korea found that, SARS-CoV-2-specific memory T cell responses were maintained at up to 8 months post-symptom onset. Among 30 individuals with longitudinal samples beyond the first month, no significant differences in memory T cell responses were observed between paired samples from different time points. The proportion of stem cell-like memory T cells peaked at 4 months post-symptom onset. Given the self-renewal capacity and multipotency of stem cell-like memory T cells, the authors suggest they may confer long-lasting memory T cell production against SARS-CoV-2.

Shin et al. (Mar 8, 2021). SARS-CoV-2-Specific T Cell Memory Is Sustained in COVID-19 Convalescents for 8 Months with Successful Development of Stem Cell-like Memory T Cells. Pre-print downloaded Mar 9 from https://doi.org/10.1101/2021.03.04.21252658