March 10, 2021

Extremely Potent Human Monoclonal Antibodies from COVID-19 Convalescent Patients

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• A study that identified highly potent human monoclonal antibodies (mAbs) found that the most potent mAbs recognized the SARS-CoV-2 spike protein receptor-binding domain, followed by those that recognized the S1 domain, the spike protein trimer, and the S2 subunit. Only 1.4% neutralized the virus with a potency of 1–10 ng/mL. The authors also engineered the most potent mAb (J08) to have an enhanced half-life and reduced risk of antibody-dependent enhancement, which neutralized wild-type virus and emerging variants containing D614G, E484K, and N501Y substitutions.  

Andreano et al. (Feb 23, 2021). Extremely Potent Human Monoclonal Antibodies from COVID-19 Convalescent Patients. Cell. https://doi.org/10.1016/j.cell.2021.02.035