March 10, 2021

Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity, variants

• [Pre-print, not peer-reviewed] Sera from individuals who had been previously infected with SARS-CoV-2 and received the vaccine showed equivalent neutralizing responses against the B.1.1.7 variant and original virus strain, while sera from vaccinated individuals with no prior infection showed reduced neutralization against B.1.1.7. Neutralizing activity was assessed against pseudoviruses bearing the spike protein from the original strain or that of the D614G or B.1.1.7 variants. 

Trinite et al. (Mar 5, 2021). Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals. Pre-print downloaded Mar 10 from https://doi.org/10.1101/2021.03.05.433800