Alliance for Pandemic Preparedness

March 10, 2021

Vaccine Effectiveness after 1st and 2nd Dose of the BNT162b2 MRNA Covid-19 Vaccine in Long-Term Care Facility Residents and Healthcare Workers – a Danish Cohort Study

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  • [Pre-print, not peer-reviewed] A retrospective registry- and population-based observational cohort study in Denmark estimated that the Pfizer/BioNTech vaccine efficacy within 7 days of receipt was 52% among long term care facility residents (LTCF, n = 39,040) and 46% among health care workers (HCW, n = 331,039), which increased to 64% and 90%, respectively, beyond 7 days of immunization. No protective effect was observed for LTCF residents after the first dose. Among HCW, efficacy was 17% > 14 days after first dose (before second dose). During a median follow-up of 53 days, there were 488 and 5,663 confirmed SARS-CoV-2 cases in the unvaccinated groups, with 57 among LTCF residents and 52 among HCW within the first 7 days following the second dose, and 27 and 10 cases beyond seven days after the second dose. 

Moustsen-Helms et al. (Mar 9, 2021). Vaccine Effectiveness after 1st and 2nd Dose of the BNT162b2 MRNA Covid-19 Vaccine in Long-Term Care Facility Residents and Healthcare Workers – a Danish Cohort Study. Pre-print downloaded Mar 10 from https://doi.org/10.1101/2021.03.08.21252200