Alliance for Pandemic Preparedness

March 11, 2021

Epidemiological and Evolutionary Considerations of SARS-CoV-2 Vaccine Dosing Regimes

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  • An immuno-epidemiological model suggests that a one-dose vaccination strategy would likely decrease short-term SARS-CoV-2 infections. Long-term outcomes, as well as likelihood of viral evolution driven by partial immunity, are mainly driven by relative immune robustness of one versus two doses. [EDITORIAL NOTE: A pre-print related to this manuscript was summarized on February 4, 2020]

Saad-Roy et al. (Mar 9, 2021). Epidemiological and Evolutionary Considerations of SARS-CoV-2 Vaccine Dosing Regimes. Science. https://doi.org/10.1126/science.abg8663