March 11, 2021

Immune Response to SARS-CoV-2 Variants of Concern in Vaccinated Individuals

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• [Pre-print, not peer-reviewed] Sera from both individuals with prior SARS-CoV-2 infection (n=35) and individuals fully vaccinated with the Pfizer-BioNTech vaccine (n=23) showed nearly identical antibody binding responses against the B.1.1.7 Cluster 5 and CAL.20C variants compared to wild-type SARS-CoV-2. In contrast, both binding and neutralizing antibody responses among vaccinated individuals were diminished against the B.1.351 variant compared to wild-type SARS-CoV-2, although the 2nd vaccine dose appeared to confer increased neutralization capacities. In a separate analysis, the authors found that individuals with prior SARS-CoV-2 infection had higher IgA antibody titers in saliva, while vaccinated individuals had high IgG titers.

Becker et al. (Mar 10, 2021). Immune Response to SARS-CoV-2 Variants of Concern in Vaccinated Individuals. Pre-print downloaded Mar 11 from https://doi.org/10.1101/2021.03.08.21252958