Alliance for Pandemic Preparedness

March 12, 2021

COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients



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  • Among patients with COVID-19 who were receiving mechanical ventilation (n=396), patients with COVID-19 associated pulmonary aspergillosis (CAPA) had higher odds of worse disease outcome, required longer time to improvement and had an increased hazard of advancing disease severity compared to those without CAPA. Although there were no differences in mortality, patients with CAPA required significantly longer median duration of any oxygen therapy (40.7 vs 16.7 days), ventilator support (36.6 vs 8.9 days) and hospital length of stay (41.1 vs 18.5 days). CAPA patients had significantly slower recovery (aOR=1.09), and progression from intubation to receipt of other advanced life support was 1.8 times faster (aHR=1.8) compared to controls. 
  • Patients with CAPA had a lower median BMI, more underlying pulmonary vascular disorders, liver disease, coagulopathy, solid tumors and multiple myeloma. COVID-19 disease severity was similar at baseline.

Permpalung et al. (Mar 9, 2021). COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients. Clinical Infectious Diseases.