Alliance for Pandemic Preparedness

March 15, 2021

Comparison of Clinical Characteristics and Disease Outcome of COVID-19 and Seasonal Influenza

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  • Compared to patients with seasonal influenza treated in hospital settings, patients with COVID-19 tended to be younger (median age 59 vs 66), had fewer comorbidities at baseline with a lower Charlson Comorbidity Index (mean 3.0 vs 4.0), had a longer duration of hospitalization (mean 25.9 vs 17.2 days), more frequently needed oxygen therapy (61% vs 40%) and invasive ventilation (31% vs 13%), and were more frequently admitted to the ICU (42% vs 20%). Among patients with compromised immune systems, those with COVID-19 had a higher hospital mortality compared to those with seasonal influenza (33% vs 12%).

Brehm et al. (Mar 11, 2021). Comparison of Clinical Characteristics and Disease Outcome of COVID-19 and Seasonal Influenza. Scientific Reports. https://doi.org/10.1038/s41598-021-85081-0