March 16, 2021

Antibody Response After SARS-CoV-2 Infection and Implications for Immunity

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune response

• A review of 66 observational studies found that most adults with SARS-CoV-2 infection develop IgM and IgG antibody responses. Among studies measuring IgM antibody responses (n=21 studies), 80% of adults developed responses, peaking at 20 days. Among studies measuring IgG antibody responses (n=24 studies), 95% of adults developed responses, peaking at 25 days and remaining detectable up to 120 days. Studies evaluating neutralizing responses (n=8 studies) were more varied in methodology, but suggest that 99% develop neutralizing antibodies.

Arkhipova-Jenkins et al. (Mar 16, 2021). Antibody Response After SARS-CoV-2 Infection and Implications for Immunity. Annals of Internal Medicine. https://doi.org/10.7326/M20-7547