March 23, 2021

Reduced BNT162b2 MRNA Vaccine Response in SARS-CoV-2-Naive Nursing Home Residents

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, vaccines

• [Pre-print, not peer-reviewed] Nursing home (NH) residents had blunted antibody responses following vaccination with BNT162b2 mRNA vaccine (Moderna) when compared to healthcare workers. SARS-CoV-2-naive NH residents mounted antibody responses with nearly 4-fold lower median neutralization titers and half the anti-spike level compared to SARS-CoV-2-naive healthcare workers. In contrast, NH residents who had recovered from infection and were subsequently vaccinated had neutralization, anti-spike, and anti-RBD titers similar to healthcare workers who had recovered from infection and were subsequently vaccinated.

Canaday et al. (Mar 22, 2021). Reduced BNT162b2 MRNA Vaccine Response in SARS-CoV-2-Naive Nursing Home Residents. Pre-print downloaded Mar 23 from https://doi.org/10.1101/2021.03.19.21253920