Alliance for Pandemic Preparedness

March 25, 2021

COVID-19 Infection Risk amongst 14104 Vaccinated Care Home Residents A National Observational Longitudinal Cohort Study in Wales United Kingdom December 2020 to March 2021

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  • [Pre-print, not peer-reviewed] Only 1% of over 14,000 nursing home residents in the UK who have received the first dose of either the Pfizer-BioNTech or Oxford-AstraZeneca vaccines reported a positive SARS-CoV-2 PCR test in an observational study from December 2020 to March 2021. 90% of infections occurred within 28 days of the first dose. At 7 days post vaccination, those with prior infection had a 46% reduced hazard of a having a positive PCR. Those who received the Pfizer-BioNTech vaccine had a 3.8-fold higher hazard of having a positive test as compared to recipients of the Oxford-AstraZeneca vaccine. At 21 days post-vaccination, individuals with low or intermediate frailty (compared to high frailty) had 4.6- and 4.9-fold higher hazard of a positive PCR test, respectively.

Hollinghurst et al. (Mar 24, 2021). COVID-19 Infection Risk amongst 14104 Vaccinated Care Home Residents A National Observational Longitudinal Cohort Study in Wales United Kingdom December 2020 to March 2021. Pre-print downloaded Mar 25 from https://doi.org/10.1101/2021.03.19.21253940