Alliance for Pandemic Preparedness

March 25, 2021

Detection of Mutations Associated with Variants of Concern Via High Throughput Sequencing of SARS-CoV-2 Isolated from NYC Wastewater

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  • [Pre-print, not peer-reviewed] Genomic analysis of wastewater samples from New York City obtained from January to March 2021 found that the SARS-CoV-2 mutations occurring at the highest frequencies where associated with known variants of concern. Mutations occurring at high frequencies include L452R, present in the CAL.20C variant first described in California, E484K, present in the B.1.351 and P.1 variants first described in South Africa and Brazil, and N50Y1 present in the B.1.1.7 variant first described in the UK as well as the B.1.351 and P.1 variants.

Smyth et al. (Mar 23, 2021). Detection of Mutations Associated with Variants of Concern Via High Throughput Sequencing of SARS-CoV-2 Isolated from NYC Wastewater. Pre-print downloaded Mar 25 from https://doi.org/10.1101/2021.03.21.21253978