March 30, 2021

Dynamics of SARS-CoV-2 Neutralising Antibody Responses and Duration of Immunity: A Longitudinal Study

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

• Five distinct patterns of SARS-CoV-2 neutralizing antibody dynamics were found in a longitudinal study of 164 SARS-CoV-2-infected patients in Singapore with follow-up of up to 180 days post-symptom onset. The different dynamics were defined by the trajectory by which antibody levels waned or evolved. Persistent dynamics, observed in the largest group of patients (32%), was characterized by minimal neutralizing antibody decay and associated with disease severity and inflammatory biomarkers. Delayed response dynamics, characterized by an unexpected increase of neutralizing titers at 90 or 180 days post-symptom onset, was observed in the smallest group (2%). Despite differing neutralizing antibody dynamics, T-cell responses were similar across groups.

Chia et al. (Mar 23, 2021). Dynamics of SARS-CoV-2 Neutralising Antibody Responses and Duration of Immunity: A Longitudinal Study. The Lancet Microbe. https://doi.org/10.1016/S2666-5247(21)00025-2