Alliance for Pandemic Preparedness

March 30, 2021

Preliminary Report on SARS-CoV-2 Spike Mutation T478K

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  • [Pre-print, not peer-reviewed] A novel mutation (T478K) located on the SARS-CoV-2 spike protein was identified in an analysis of over 820,000 genomic sequences deposited on the global genome database GISAID up to March 26, 2021. Since its identification in the beginning of 2021, T478K is present in almost 2% of all sequenced genomes. Among the detected 4,214 distinct cases, 86% are associated with the B.1.1.222 variant first described in Mexico, and the mutation is present in 65% of B.1.1.222 cases in GISAID. Among the cases, 29% (1,203) originated from Mexico (constituting 38% of all sequenced genomes from Mexico) and 60% (2,536) originated from the US (constituting 1.3% of all sequenced genomes from the US).

Giacomo et al. (Mar 29, 2021). Preliminary Report on SARS-CoV-2 Spike Mutation T478K. Pre-print downloaded Mar 30 from https://doi.org/10.1101/2021.03.28.437369