April 1, 2021

Longitudinal Dynamics of Antibody Responses in Recovered COVID-19 Patients

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

• SARS-CoV-2-specific IgG antibody titers gradually increased with neutralizing antibody titers while IgM titers more quickly waned in a study of the antibody response dynamics in 24 COVID-19 recovered patients followed up to 42 weeks. While IgG titers were higher among severe than among mild cases, titers did not decline significantly over time in either group. 17% of patients were IgM-negative by 8-11 weeks, and the proportion continued to increase during the following weeks. Neutralizing antibody titers initially showed significant drops up to week 13, but remained stable through 42 weeks.

Cheng et al. (Mar 31, 2021). Longitudinal Dynamics of Antibody Responses in Recovered COVID-19 Patients. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-021-00559-7