Alliance for Pandemic Preparedness

April 5, 2021

Infection- and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant

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  • Acutely infected COVID-19 patients and those who received the Moderna vaccine had significantly reduced IgG binding to the B.1.351 variant receptor binding domain (RBD) compared to the B.1-lineage RBD-specific IgG response. However, sera containing polyclonal antibodies to the spike protein could still effectively neutralize B.1.351. Individuals with prior infection or vaccinated individuals had a nearly 3-fold reduction in binding antibody titers to the B.1.351 variant against the RBD of the spike protein and a 3.5-fold reduction in neutralizing antibody titers compared to the B.1 variant.

Edara et al. (Mar 2021). Infection- and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2021.03.009