Alliance for Pandemic Preparedness

April 5, 2021

Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection

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  • A study of hospitalized and non-hospitalized symptomatic patients (n = 210 samples, 84 patients) over a period of 10 months using six different commercial assays for antibody detection found that assays targeting total antibodies presented higher positivity rates and reached the highest positivity rates sooner than assays directed against IgG alone. The inter-assay agreement was also higher between assays targeting total antibody levels. Antibody assays evaluated were the Roche RBD total Ab, Roche NCP total Ab, DiaSorin S1+S2 IgG, Ortho S1 IgG, Ortho S1 total Ab, and Phadia S1 IgG. 

Favresse et al. (Mar 8, 2021). Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection. Microorganisms. https://doi.org/10.3390/microorganisms9030556