Alliance for Pandemic Preparedness

April 5, 2021

SARS-CoV-2 Infection Is Asymptomatic in Nearly Half of Adults with Robust Anti-Spike Protein Receptor-Binding Domain Antibody Response

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  • In a study of 4996 participants (aged 18–82 years, 34.5% men) from Greece with plasma antibodies against SARS-CoV-2 nucleocapsid protein between June and November 2020, 49% of seropositive cases (39/79) reported no history of SARS-CoV-2 infection-related clinical symptoms. The majority of SARS-CoV-2 asymptomatic infections were “unsuspected” cases (26/39) who had no known contact with a confirmed or suspected COVID-19 case. Anti-SARS-CoV-2 antibody levels against the spike-protein receptor binding domain were similar between symptomatic and asymptomatic individuals, with no differences by age or gender.

Tsitsilonis et al. (Mar 2, 2021). SARS-CoV-2 Infection Is Asymptomatic in Nearly Half of Adults with Robust Anti-Spike Protein Receptor-Binding Domain Antibody Response. Vaccines. https://doi.org/10.3390/vaccines9030207