Alliance for Pandemic Preparedness

April 6, 2021

Genomic Surveillance of Nevada Patients Revealed Prevalence of Unique SARS-CoV-2 Variants Bearing Mutations in the RdRp Gene

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  • A novel SARS-CoV-2 mutation (P323 F/L) in the non-structural protein ORF was identified using a genomic surveillance sample of 200 high quality sequences obtained in Nevada from March to June 2020. Phylogenetic reconstruction of the samples cross-referenced to a subsample of sequences in the Nextstrain global genome database show that variants with the mutation P323L have been identified across the world, while variants with the mutation P323F was only noted in North America. Because this mutation is located in a region required to coordinate polymerase activity, the authors are conducting further investigations to determine whether there are phenotypic consequences to this mutation. 

Hartley et al. (Feb 18, 2021). Genomic Surveillance of Nevada Patients Revealed Prevalence of Unique SARS-CoV-2 Variants Bearing Mutations in the RdRp Gene. Journal of Genetics and Genomics. https://doi.org/10.1016/j.jgg.2021.01.004