April 7, 2021

Antibody Persistence through 6 Months after the Second Dose of MRNA-1273 Vaccine for Covid-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, vaccines

• Neutralizing antibody activity elicited by the Moderna vaccine remained high 6 months after the second dose in all 33 adults in an ongoing phase 1 trial, as measured by 3 different serologic assays. Binding antibody half-life estimates after day 43 for all the participants were 52 days when calculated via an exponential decay model (assumes a steady decay rate), and 109 days via a power-law model at day 119 (assumes decay rates decrease over time). Neutralizing antibody half-life estimates in the two models were 69 days and 173 days for pseudovirus neutralization, and 68 days and 202 days for live-virus neutralization. 

Doria-Rose et al. (Apr 6, 2021). Antibody Persistence through 6 Months after the Second Dose of MRNA-1273 Vaccine for Covid-19. New England Journal of Medicine. https://doi.org/10.1056/NEJMc2103916