April 8, 2021

Humoral and Cellular Immunogenicity of the BNT162b2 MRNA Covid-19 Vaccine in Nursing Home Residents

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): congregate settings, immune response, vaccine

• Nursing home residents who had a prior SARS-CoV-2 infection were more likely than those with no history of infection to have an immunologic response within 1 week of the second dose of the Pfizer-BioNtech vaccine. Among nursing home residents in Belgium, humoral and cellular responses elicited by vaccination with the Pfizer-BioNtech vaccine were detected in 97% of those with prior SARS-CoV-2 infection (n=64) 1 week after the second dose (4 weeks after the first dose) but in only 37% of infection-naïve residents (n=46). In comparison, vaccine-elicited humoral and cellular responses were detected in 87% of 15 infection-naïve healthcare workers serving as controls.

Van Praet et al. (Apr 7, 2021). Humoral and Cellular Immunogenicity of the BNT162b2 MRNA Covid-19 Vaccine in Nursing Home Residents. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab300