Alliance for Pandemic Preparedness

April 13, 2021

Rapid Decline of Neutralizing Antibodies Is Associated with Decay of IgM in Adults Recovered from Mild COVID-19 Disease

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  • SARS-CoV-2-specific IgG antibody levels were relatively stable for up to 6 months, whereas neutralizing antibody responses waned during that time, according to a cohort study of 34 adults with mild COVID-19. By 6 months, only 70% (23 of 33) of participants exhibited a neutralizing response compared to 91% or higher for IgG antibody responses. Presence of fever was associated with higher IgG antibody responses, while declining IgM antibody levels were strongly associated with declines in neutralizing activity.

Harrington et al. (Mar 24, 2021). Rapid Decline of Neutralizing Antibodies Is Associated with Decay of IgM in Adults Recovered from Mild COVID-19 Disease. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2021.100253