Alliance for Pandemic Preparedness

April 15, 2021

Early T Cell and Binding Antibody Responses Are Associated with Covid-19 RNA Vaccine Efficacy Onset

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  • In a cohort of 20 healthcare workers receiving the first dose of the Pfizer-BioNTech vaccine, SARS-CoV-2 spike-specific memory T-cell and binding antibody responses were universally detected prior to the time where vaccine efficacy is first detected in clinical trials (day 12). In contrast, receptor blocking and neutralizing antibodies were not detected on day 7 and present only in 20% of individuals by day 10.

Kalimuddin et al. (Apr 8, 2021). Early T Cell and Binding Antibody Responses Are Associated with Covid-19 RNA Vaccine Efficacy Onset. Med. https://doi.org/10.1016/j.medj.2021.04.003