April 15, 2021

MRNA Vaccination Compared to Infection Elicits an IgG-Predominant Response with Greater SARS-CoV-2 Specificity and Similar Decrease in Variant Spike Recognition

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccination, variant

• [Pre-print, not peer-reviewed] Immune serological responses against SARS-CoV-2 among 55 recipients of the Pfizer-BioNTech vaccine were dominated by IgG antibody responses compared to more diverse responses (including IgM and IgA) elicited by natural infection among 100 COVID-19 patients. Vaccinated individuals also had decreased breadth of antibody response against endemic human coronaviruses compared to convalescent individuals. Similar to other studies, antibody binding among both vaccinees and convalescent individuals progressively decreased for B.1.1.7, P.1 and B.1.351 compared to the parent strain.

Röltgen et al. (Apr 7, 2021). MRNA Vaccination Compared to Infection Elicits an IgG-Predominant Response with Greater SARS-CoV-2 Specificity and Similar Decrease in Variant Spike Recognition. Pre-print downloaded Apr 15 from https://doi.org/10.1101/2021.04.05.21254952