Alliance for Pandemic Preparedness

April 15, 2021

Neutralizing Activity of Sputnik V Vaccine Sera against SARS-CoV-2 Variants

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  • [Pre-print, not peer-reviewed] Neutralizing antibody activity induced by SARS-CoV-2 adenovirus vector vaccine Sputnik V had geometric mean titers (GMT) that were reduced by 6.8-fold against a pseudovirus bearing B.1.351 spike protein mutations when compared to the prototypic D614G strain. GMT reduction was reduced by 2.8-fold against the pseudovirus with the E484K mutation alone. Among the 12 serum samples collected from fully vaccinated individuals from Argentina, only 1 effectively neutralized the B.1.351 pseudovirus at concentrations present in serum (undilute). By contrast, the same set of sera efficiently neutralized a pseudovirus bearing the B.1.1.7 mutations.

Ikegame et al. (Apr 8, 2021). Neutralizing Activity of Sputnik V Vaccine Sera against SARS-CoV-2 Variants. Research Square. https://doi.org/10.21203/rs.3.rs-400230/v1