April 15, 2021

Sera Neutralizing Activities against SARS-CoV-2 and Multiple Variants Six Month after Hospitalization for COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune response, immunity, variants

• Neutralizing activity in sera of SARS-CoV-2 infected individuals (n=104) against the variants D614G, B.1.1.7, and P.1 up to 6 months after infection was similar compared to the prototypic strain isolated originally in Wuhan, but was reduced 3-fold against the B.1.351 variant. Similar to other studies, anti-spike and anti-nucleocapsid IgG levels waned over time (2.8% reverted to seronegative status by 6 months), and higher neutralizing activity was observed among individuals with a more severe disease course.

Betton et al. (Apr 14, 2021). Sera Neutralizing Activities against SARS-CoV-2 and Multiple Variants Six Month after Hospitalization for COVID-19. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab308