Alliance for Pandemic Preparedness

April 15, 2021

Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells

Category:

Topic:

Keywords (Tags): , ,

  • [Pre-print, not peer-reviewed] SARS-CoV-2 specific B cells isolated from individuals who had recovered from SARS-CoV-2 infection appeared similar to B cells isolated previously described in individuals with chronic infections or inflammation (IgD negative, CD27 negative), according to a longitudinal study of convalescent individuals (n=22). After vaccination, the frequency of IgD/CD27 negative cells (“double negative”) decreased. A more robust immune response elicited by vaccination among individuals with prior infection compared to naïve individuals was documented by comparing memory B cell responses of this cohort with those of non-infected vaccinated controls.

Mishra et al. (Apr 14, 2021). Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells. Pre-print downloaded Apr 15 from https://doi.org/10.1101/2021.04.11.21255153