April 16, 2021

Spike Antibody Levels of Nursing Home Residents With or Without Prior COVID-19 3 Weeks After a Single BNT162b2 Vaccine Dose

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune response, vaccine

• Nursing home residents with a past history of COVID-19 were far more likely than those without a history of COVID-19 to mount an antibody response to the first dose of the Pfizer-BioNTech vaccine. Among a cohort of nursing home residents in France, all 36 residents with prior COVID-19 were seropositive for anti-spike (S) IgG antibodies after one Pfizer-BioNTech vaccine dose compared to 29 (48%) of 60 residents without prior COVID-19. The participants were tested for anti-S IgG just prior to receiving the second dose. The anti-S IgG median titer of participants with prior COVID-19 were much higher than of those without prior COVID-19 (≥40,000 vs 48 AU/mL). Prior to testing, 72% of participants with prior COVID-19 were seropositive for anti-nucleocapsid (N) IgG.

Blain et al. (Apr 15, 2021). Spike Antibody Levels of Nursing Home Residents With or Without Prior COVID-19 3 Weeks After a Single BNT162b2 Vaccine Dose. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2778926