Alliance for Pandemic Preparedness

April 19, 2021

Humoral and Cellular Immune Responses against SARS-CoV-2 Variants and Human Coronaviruses after Single BNT162b2 Vaccination

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  • [Pre-print, not peer-reviewed] An assessment of humoral and T cell responses against a wild type SARS-CoV-2 strain, variants of concern (B.1.1.7, B.1.351, and P.1), and endemic human coronaviruses (hCov) induced after the Pfizer-BioNTech vaccine found that IgG against the receptor-binding domain of the SARS-CoV-2 S protein was readily detectable at day 14, but inhibition of SARS-CoV-2 S-driven host cell entry was weak and particularly low for the B.1.351 variant. After one vaccine dose, frequencies of SARS-CoV-2 specific T cells were low in many vaccine recipients and influenced by immunity against endemic hCoV. The second vaccination significantly boosted T cell frequencies reactive for the wild type SARS-CoV-2 strain, as well as B.1.1.7 and B.1.351 variants. 

Stankov et al. (Apr 16, 2021). Humoral and Cellular Immune Responses against SARS-CoV-2 Variants and Human Coronaviruses after Single BNT162b2 Vaccination. Pre-print downloaded Apr 19 from https://doi.org/10.1101/2021.04.16.21255412